Though it suffered as much as the rest of the planet from the Zentraedi Holocaust, the ecosystem in South America was much faster to recover despite not being part of the Natural Recovery Planning Zone. Within a few years most of the wasteland was reclaimed by the dense jungles. Unfortunately, the dense jungles became a haven for militant Zentraedi. For years the jungles of the Amazon were home to thousands, perhaps even millions, of rogue Zentraedi. What human civilization that remained clustered around the massive military presence set up by the Robotech Defense Force (RDF) to contain the Zentraedi threat. The Malcontent Uprisings saw the final defeat of the militant Zentraedi forces, though even today the South American jungles are still home to a few of the rogue aliens remaining on Earth.
- A portion of Robotech: The New Generation took place in South America, as Scott Bernard's band of freedom fighters made their way to Reflex Point.